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Krichevsky, Oleg

Krichevsky, Oleg
Research type
Research topics

Interactions and physical properties of biological molecules; Advanced optical and molecular biology techniques.

Researcher identification
Google Scholar, ORCID

Research highlights

Internal dynamics of biological polymers: DNA molecules, actin filaments

Internal dynamics of biological polymers: DNA molecules, actin filaments
The dynamics of a semi-flexible polymer

The problem of polymer dynamics is rather old, going back to the 1930-s.
How the stochastic thermal motion (diffusion) reveals itself in the dynamics of polymer segments which are bound by connectivity along the chain, by polymer stiffness, by topological constrains, by hydrodynamic and other interactions?
The question does not have simple solutions in neither theory, computer simulations, or experiments. We have developed an original experimental approach to measure the dynamics of biological polymers, such as DNA at the level of single monomer with high temporal and spatial resolution.

Additional research highlights


  1. Oyler-Yaniv, A. and Oyler-Yaniv, J. and Whitlock, B.M. and Liu, Z. and Germain, R.N. and Huse, M. and Altan-Bonnet, G. and Krichevsky, O., "A Tunable Diffusion-Consumption Mechanism Of Cytokine Propagation Enables Plasticity In Cell-To-Cell Communication In The Immune System", Immunity 46, 609-620 (2017)
  2. Oyler-Yaniv, J. and Oyler-Yaniv, A. and Shakiba, M. and Min, N.K. and Chen, Y. and Cheng, S. and Krichevsky, O. and Altan-Bonnet, N. and Altan-Bonnet, G., "Catch And Release Of Cytokines Mediated By Tumor Phosphatidylserine Converts Transient Exposure Into Long-Lived Inflammation", Molecular Cell 66, 635-647.e7 (2017)
  3. Raz-Ben Aroush, D. and Ofer, N. and Abu-Shah, E. and Allard, J. and Krichevsky, O. and Mogilner, A. and Keren, K., "Actin Turnover In Lamellipodial Fragments", Current Biology 27, 2963-2973.e14 (2017)
  4. Nepal, Manish And Oyler-Yaniv, Alon And Krichevsky, Oleg, "Scanning Fluorescence Correlation Spectroscopy As A Versatile Tool To Measure Static And Dynamic Properties Of Soft Matter Systems", Soft Matter 11, 8939-8947 (2015)
  5. Krichevsky, Oleg, "Comment On ``Polymer Dynamics, Fluorescence Correlation Spectroscopy, And The Limits Of Optical Resolution″", Physical Review Letters 110, 159801 (2013)
  6. Nepal, Manish And Yaniv, Alon And Shafran, Eyal And Krichevsky, Oleg, "Structure Of Dna Coils In Dilute And Semidilute Solutions", Physical Review Letters 110, 058102 (2013)
  7. Krichevsky, Oleg, "T4 Lysozyme As A Pac-Man: How Fast Can It Chew?", Biophysical Journal 103, 1414-1415 (2012)
  8. Krichevsky, Oleg, "Dna Overstretched State: S-Dna Form Or Force-Induced Melting? Comment On ``Biophysical Characterization Of Dna Binding From Single Molecule Force Measurements″ By Mark C. Williams Et Al.", Physics Of Life Reviews 7, 350-352 (2010)
  9. Shafran, Eyal And Yaniv, Alon And Krichevsky, Oleg, "Marginal Nature Of Dna Solutions", Physical Review Letters 104, 128101 (2010)
  10. Soriano, Jordi And Braslavsky, Ido And Xu, Di And Krichevsky, Oleg And Stavans, Joel, "Universality Of Persistence Exponents In Two-Dimensional Ostwald Ripening", Physical Review Letters 103, 226101 (2009)
  11. Wocjan, Tomasz And Krieger, Jan And Krichevsky, Oleg And Langowski, Joerg, "Dynamics Of A Fluorophore Attached To Superhelical Dna: Fcs Experiments Simulated By Brownian Dynamics", Physical Chemistry Chemical Physics 11, 10671-10681 (2009)
  12. Shusterman, Roman And Gavrinyov, Tatyana And Krichevsky, Oleg, "Internal Dynamics Of Superhelical Dna", Physical Review Letters 100, 098102 (2008)
  13. Ambjornsson, Tobias And Banik, Suman K. And Krichevsky, Oleg And Metzler, Ralf, "Breathing Dynamics In Heteropolymer Dna", Biophysical Journal 92, 2674-2684 (2007)
  14. Romantsov, Tatyana And Fishov, Itzhak And Krichevsky, Oleg, "Internal Structure And Dynamics Of Isolated Escherichia Coli Nucleoids Assessed By Fluorescence Correlation Spectroscopy", Biophysical Journal 92, 2875-2884 (2007)
  15. Ambjornsson, Tobias And Banik, Suman K. And Krichevsky, Oleg And Metzler, Ralf, "Sequence Sensitivity Of Breathing Dynamics In Heteropolymer Dna", Physical Review Letters 97, 128105 (2006)
  16. Bernheim-Groswasser, Anne And Shusterman, Roman And Krichevsky, Oleg, "Fluorescence Correlation Spectroscopy Analysis Of Segmental Dynamics In Actin Filaments", Journal Of Chemical Physics 125, 084903 (2006)
  17. Shusterman, R And Alon, S And Gavrinyov, T And Krichevsky, O, "Monomer Dynamics In Double- And Single-Stranded Dna Polymers", Physical Review Letters 92, 048303 (2004)
  18. Altan-Bonnet, G And Libchaber, A And Krichevsky, O, "Bubble Dynamics In Double-Stranded Dna", Physical Review Letters 90, 138101 (2003)
  19. Goddard, N And Bonnet, G And Krichevsky, O And Libchaber, A, "Misfolded Loops Decrease The Effective Rate Of Dna Hairpin Formation - Reply", Physical Review Letters 88, 069802 (2002)
  20. Krichevsky, O And Bonnet, G, "Fluorescence Correlation Spectroscopy: The Technique And Its Applications", Reports On Progress In Physics 65, 251-297 (2002)