What are hydrotropes and can they be selective? Creating selectivity from non-selective interactions

by Prof. Daniel Harries

Institute Of Chemistry, The Hebrew University Of Jerusalem

at Biological and soft-matter physics

Thu, 18 Jun 2020, 12:10
TODAY - ZOOM meeting ID: 919-198-85007 Password: 2q35r3

Abstract

The aggregation of drugs and nutraceuticals in aqueous media is an outstanding problem for their efficacy and bioavailability. A common solution is to add excipients or hydrotropes that increase solubility and limit aggregation through weak and nonspecific interactions. Hydrotropes are distinct from other additives because they do not form mesophases in solution, and therefore present a completely different strategy to counteracting hydrophobicity. In this talk I will describe how we have been able to find hydrotropes that act selectively, since they differentially act on specific solvated forms of hydrophobic molecules. I will furthermore describe the molecular mechanism for this selectivity, and comment on the general design principles that should help develop targeted excipients for bioavailability and taste modification in drugs and foods.

References
(1) I. Shumilin, C. Allolio, D. Harries. JACS 45:18056 (2019).
(2) I. Shumilin, B. Bogoslavsky, D. Harries. Colloids and Surfaces A 599:124889 (2020).

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Meeting ID: 919 1988 5007
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Created on 23-02-2020 by Granek, Rony (rgranek)
Updaded on 18-06-2020 by Granek, Rony (rgranek)