Active-gel Theory for Multicellular Migration

by Dr. Ram Adar

College de France and Institut Curie

at Biological and soft-matter physics

Thu, 03 Nov 2022, 12:10
Sacta-Rashi Building for Physics (54), room 207

Abstract

Active materials are driven out of equilibrium by a constant consumption of energy at the microscopic level, which is converted into forces and motion. These include biological objects at different scales, ranging from active molecular motors to groups of animals. The physical theory that I will present is motivated by multicellular migration in tissues, which plays a key role in development, wound healing, and metastasis. We propose to describe it as permeation of an active, polar solvent in a viscoelastic environment. We formulate an active-gel theory that provides a simple description of the dynamic reciprocity between migrating cells and their environment in terms of distinct relative forces and alignment mechanisms. We make new predictions regarding multicellular migration modes based on these mechanisms. Namely, cellular alignment to elastic strains is expected to drive phase-separation in the cellular concentration and orientation for sufficiently extensile collections of cells. Our theory can serve as basis for the analysis of multicellular migration modes and cancer-cell invasion from tumors into connective tissues.

Created on 31-10-2022 by Feingold, Mario (mario)
Updaded on 31-10-2022 by Feingold, Mario (mario)