In recent years, Molecular Biology is undergoing a true revolution. A number of technological breakthroughs enable data generation many orders of magnitude faster than ever. In parallel with this revolution in experimental methods, the emerging fields of bioinformatics and systems' biology aim at filling the huge gap in appropriate quantitative analysis methods. I will try to give a flavor of the problems facing us, concentrating on the role currently played by physicists' working in these fields, and where else can we go.