Partial derivatives and differentials

For the function:
U(x,y,z)=\frac{1}{[x^2+y^2+z^2]^{\frac{3}{2}}}     
Compute:  
\frac{\partial U(x,y,z)}{\partial x}  ,   \frac{\partial^2 U(x,y,z)}{{\partial y}^2}  ,   \frac{\partial^2 U(x,y,z)}{\partial y\partial z}
and the full differential -  dU .